Hydrochloric Acid → HCID 86705511, compound

Participants

Reaction Steps

To a solution of 226 (0.350 g, 1.17 mmol) in dioxane (5 mL) was added 4N HCl in dioxane (2.93 mL, 11.7 mmol) and stirred for 1 h at RT then concentrated to dryness which afforded 0.2 g (72.6%) of (R)-3-amino-3-(3-chloro-4-fluorophenyl)propanenitrile hydrochloride (228), which was used without further purification.

Provenance & Evidence