Hydrochloric Acid → HCID 86705511, compound

HRID 2279514Notes

Reaction equation

HRID 2279514 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C@H:9]([NH:13]C(=O)OC(C)(C)C)[CH2:10][C:11]#[N:12])[CH:5]=[CH:6][C:7]=1[F:8].Cl>O1CCOCC1>[ClH:1].[NH2:13][C@@H:9]([C:4]1[CH:5]=[CH:6][C:7]([F:8])=[C:2]([Cl:1])[CH:3]=1)[CH2:10][C:11]#[N:12]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86705512HCID 86705512, compound

Product 1

HCID 86705511HCID 86705511, compoundYield 145.4%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of 226 (0.350 g, 1.17 mmol) in dioxane (5 mL) was added 4N HCl in dioxane (2.93 mL, 11.7 mmol) and stirred for 1 h at RT then concentrated to dryness which afforded 0.2 g (72.6%) of (R)-3-amino-3-(3-chloro-4-fluorophenyl)propanenitrile hydrochloride (228), which was used without further purification.

Workup

  1. concentrationthen concentrated to dryness which

Sources & evidence

ORD record
ord-24514847eb17400287558498f68c93f6
Source dataset
uspto-grants-2015_09
Patent number
US09133187B2

Reaction notes

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