Methylamine → HCID 86705524, compound

Participants

Reaction Steps

To a solution of 258 (1.0 g, 3.5 mmol) and THF (20 mL) at RT was added methylamine (2.7 g, 35 mmol, 40% in water) and the reaction was sealed and stirred for 24 h at RT. The reaction was then concentrated to afford 0.83 g (100%) of (R)-1-(3-fluoro-4-(trifluoromethyl)phenyl)-2-(methylamino)ethanol (260) which was used without further purification.

Provenance & Evidence