Methylamine → HCID 86705524, compound

HRID 2279525Notes

Reaction equation

HRID 2279525 reaction equation
Br[CH2:2][C@@H:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[C:7]([F:15])[CH:6]=1)[OH:4].[CH3:16][NH2:17]>C1COCC1>[F:15][C:7]1[CH:6]=[C:5]([C@@H:3]([OH:4])[CH2:2][NH:17][CH3:16])[CH:10]=[CH:9][C:8]=1[C:11]([F:14])([F:13])[F:12]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 86705523HCID 86705523, compound

Product 1

HCID 86705524HCID 86705524, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 258 (1.0 g, 3.5 mmol) and THF (20 mL) at RT was added methylamine (2.7 g, 35 mmol, 40% in water) and the reaction was sealed and stirred for 24 h at RT. The reaction was then concentrated to afford 0.83 g (100%) of (R)-1-(3-fluoro-4-(trifluoromethyl)phenyl)-2-(methylamino)ethanol (260) which was used without further purification.

Workup

  1. customthe reaction was sealed
  2. concentrationThe reaction was then concentrated

Sources & evidence

ORD record
ord-c61410b4099447ed8b9e4d0d042a417e
Source dataset
uspto-grants-2015_09
Patent number
US09133187B2

Reaction notes

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