反应详情

To a solution 292 (0.090 g, 0.16 mmol) and DCM (3 mL) at RT was added TFA (1 mL) and the reaction was stirred at RT for 1 h and then concentrated to dryness. The resulting product was next dissolved in minimal DCM (using MeOH to aid solubility) and added to a stirring solution of 1M HCl in ether. The resulting solid was filtered, washed with ether and dried to afford 0.060 g (75%) of I-72: MS m/z (APCI-pos) M+1=455.

1. concentrationconcentrated to dryness
2. dissolutionThe resulting product was next dissolved in minimal DCM (using MeOH to aid solubility)
3. additionadded to a stirring solution of 1M HCl in ether
4. filtrationThe resulting solid was filtered
5. washwashed with ether
6. customdried
7. customto afford 0.060 g (75%) of I-72