HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 86705536, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 2-Fluoro-4-(trifluoromethyl)phenylacetic acid | HCID 3863567 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86705536 | HCID 86705536 | 96% |
Reaction Steps
To a solution of 2-(2-fluoro-4-(trifluoromethyl)phenyl)acetic acid (5 g, 22.509 mmol, CASRN 209991-64-0) in DCM (112 mL, 22.509 mmol) was added oxalyl chloride (2.94 mL, 33.8 mmol) and 3 drops of DMF. The solution was stirred at RT overnight and concentrated to dryness to afford 5.2 g (88.2%) of 2-(2-fluoro-4-(trifluoromethyl)phenyl)acetyl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133187B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-2a967aaefce7479188a9b0c9705f9fc1 |
| Source note | uspto-grants-2015_09 |