Dichloromethane → HCID 86705536, compound

HRID 2279549Notes

Reaction equation

HRID 2279549 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[CH2:12][C:13]([OH:15])=O.C(Cl)[Cl:17].C(Cl)(=O)C(Cl)=O>CN(C=O)C>[F:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[CH2:12][C:13]([Cl:17])=[O:15]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 65578Oxalyl chlorideHCID 38635672-Fluoro-4-(trifluoromethyl)phenylacetic acid

Product 1

HCID 86705536HCID 86705536, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideCatalyst

Procedure

To a solution of 2-(2-fluoro-4-(trifluoromethyl)phenyl)acetic acid (5 g, 22.509 mmol, CASRN 209991-64-0) in DCM (112 mL, 22.509 mmol) was added oxalyl chloride (2.94 mL, 33.8 mmol) and 3 drops of DMF. The solution was stirred at RT overnight and concentrated to dryness to afford 5.2 g (88.2%) of 2-(2-fluoro-4-(trifluoromethyl)phenyl)acetyl chloride.

Workup

  1. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-2a967aaefce7479188a9b0c9705f9fc1
Source dataset
uspto-grants-2015_09
Patent number
US09133187B2

Reaction notes

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