反应详情

To a solution of 428 (0.085 g, 0.347 mmol) and DCM (15 mL) was added TEA (1 mL) and CDI (0.149 g, 0.919 mmol). The mixture was stirred at RT for 1 h and then 28 (0.081 g, 0.35 mmol) was added. The reaction was stirred at RT for 2 h. The solvent was removed in vacuo and the residue was purified by preparative reverse HPLC to afford 31 mg (28%) of I-151 as a white solid: LC-MS (ESI) m/z 505 (M+H).

1. stirringThe reaction was stirred at RT for 2 h
2. customThe solvent was removed in vacuo
3. customthe residue was purified by preparative reverse HPLC
4. customto afford 31 mg (28%) of I-151 as a white solid