HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Methylamino)adamantane → HCID 178522750, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Methylamino)adamantane | HCID 19476 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | HCID 178524805 | HCID 178524805 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178522750 | HCID 178522750 | — |
Reaction Steps
BOP (2.6 g, 5.8 mmol) is added to a solution of 3-trifluoromethyl-1H-pyrazole-4-carboxylic acid (1.0 g, 5.55 mmol), admantan-1-yl-methylamine (959 mg, 5.8 mmol), HOBt (200 mg, 1.4 mmol) and DIEA (1.1 mL, 6.5 mmol) in DMF (25 mL) at RT. The mixture is stirred for 14 h. The mixture is poured into a sat. NH4Cl (450 mL) and filtered to afford the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133204B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-2e4cc8cde4a447e8bbe39bb9172222a2 |
| Source note | uspto-grants-2015_09 |