Sodium Hydroxide → HCID 59579953, compound

HRID 2279610Notes

Reaction equation

HRID 2279610 reaction equation
[NH2:1][C:2]1[C:7]([F:8])=[CH:6][N:5]=[C:4]([N:9]2[CH:13]=[C:12]([C:14]([O:16]CC)=[O:15])[C:11]([C:19]([F:22])([F:21])[F:20])=[N:10]2)[N:3]=1.[OH-].[Na+]>CO>[NH2:1][C:2]1[C:7]([F:8])=[CH:6][N:5]=[C:4]([N:9]2[CH:13]=[C:12]([C:14]([OH:16])=[O:15])[C:11]([C:19]([F:22])([F:21])[F:20])=[N:10]2)[N:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 59579911HCID 59579911, compound

Product 1

HCID 59579953HCID 59579953, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of ethyl 1-(4-amino-5-fluoropyrimidin-2-yl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate (269 mg, 0.84 mmol) and NaOH (2 mL, 10N) in MeOH is heated to 45° C. for 2 h. The solvent is removed to dryness. H2O is added. The solution is acidified with 2N HCl to pH=5, to afford the title compound as an off-white solid.

Workup

  1. customThe solvent is removed to dryness
  2. additionH2O is added

Sources & evidence

ORD record
ord-f0686ddea44e48d1a30be91e7afd0072
Source dataset
uspto-grants-2015_09
Patent number
US09133204B2

Reaction notes

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