Sodium Hydroxide → HCID 59579953, compound

Participants

Reaction Steps

A solution of ethyl 1-(4-amino-5-fluoropyrimidin-2-yl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate (269 mg, 0.84 mmol) and NaOH (2 mL, 10N) in MeOH is heated to 45° C. for 2 h. The solvent is removed to dryness. H2O is added. The solution is acidified with 2N HCl to pH=5, to afford the title compound as an off-white solid.

Provenance & Evidence