Acetic Anhydride → HCID 178469792, compound

HRID 2279620Notes

Reaction equation

HRID 2279620 reaction equation
[C:1](OC(=O)C)(=[O:3])[CH3:2].[OH:8][C:9]1[C:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:12][NH:11][N:10]=1>C(O)(=O)C>[C:1]([N:11]1[CH:12]=[C:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:9]([OH:8])=[N:10]1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 178469940HCID 178469940, compound

Product 1

HCID 178469792HCID 178469792, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Acetic anhydride (1.2 mL, 12.8 mmol) is added to a suspension of ethyl 3-hydroxy-1H-pyrazole-4-carboxylate (2.0 g, 12.8 mmol) in 30 mL of acetic acid. The reaction mixture is stirred at RT for 2 h. The solvent is removed in vacuo, and the remaining solid is washed with water, collected by vacuum filtration, and dried in vacuo to give the title compound as a white solid. 1H NMR (400 MHz, CDCl3) δ 8.45 (1H, s), 8.27 (1H, bs), 4.38 (2H, q), 2.64 (3H, s), 1.38 (3H, t).

Workup

  1. customThe solvent is removed in vacuo
  2. washthe remaining solid is washed with water
  3. filtrationcollected by vacuum filtration
  4. customdried in vacuo

Sources & evidence

ORD record
ord-e83cabbcce57432f91e49087780ee621
Source dataset
uspto-grants-2015_09
Patent number
US09133204B2

Reaction notes

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