Hydrochloric Acid → HCID 59579844, compound

HRID 2279623Notes

Reaction equation

HRID 2279623 reaction equation
[OH-].[Na+].[CH3:3][O:4][C:5]1[C:9]([C:10]([O:12]CC)=[O:11])=[CH:8][N:7]([C:15]2[N:20]=[CH:19][CH:18]=[CH:17][N:16]=2)[N:6]=1.O.Cl>CCO>[CH3:3][O:4][C:5]1[C:9]([C:10]([OH:12])=[O:11])=[CH:8][N:7]([C:15]2[N:20]=[CH:19][CH:18]=[CH:17][N:16]=2)[N:6]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 59580029HCID 59580029, compound

Product 1

HCID 59579844HCID 59579844, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A 1 N aqueous sodium hydroxide solution (10 mL) is added to a slurry of ethyl 3-methoxy-1-pyrimidin-2-yl-1H-pyrazole-4-carboxylate (1.1 mg, 4.43 mmol) in 30 mL of EtOH. The reaction mixture becomes homogeneous and is stirred for 2 h at RT. Water (2-3 mL) is added, and the solution is cooled to 0° C. and acidified to pH=2-3 with cone. HCl. Most of the EtOH is removed in vacuo, and the resultant mixture is filtered. The collected solid is dried in vacuo to give the title compound as a white solid.

Workup

  1. temperaturethe solution is cooled to 0° C.
  2. customMost of the EtOH is removed in vacuo
  3. filtrationthe resultant mixture is filtered
  4. customThe collected solid is dried in vacuo

Sources & evidence

ORD record
ord-c458768b6f12405684c258ffa5a1963f
Source dataset
uspto-grants-2015_09
Patent number
US09133204B2

Reaction notes

Loading…