Sodium Hydroxide → 5-Benzyl-1,3-dimethyl-1H-pyrazole-4-carboxylic acid

HRID 2279642Notes

Reaction equation

HRID 2279642 reaction equation
[OH-].[Na+].C[O:4][C:5]([C:7]1[C:8]([CH3:20])=[N:9][N:10]([CH3:19])[C:11]=1[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:6]>CO>[CH2:12]([C:11]1[N:10]([CH3:19])[N:9]=[C:8]([CH3:20])[C:7]=1[C:5]([OH:6])=[O:4])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 154462275-benzyl-1,3-dimethyl-1H-pyrazole-4-carboxylic acid methyl ester

Product 1

HCID 595799845-Benzyl-1,3-dimethyl-1H-pyrazole-4-carboxylic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

NaOH (10 N, 7 mL) is added to a solution of 5-benzyl-1,3-dimethyl-1H-pyrazole-4-carboxylic acid methyl ester (680 mg, 2.78 mmol) in MeOH (10 mL) at RT. The mixture is heated to 50° C. for 4 h. The solvent is removed to dryness. H2O is added and pH is adjusted to 5 using aq. HCl. The solid is filtered and dried to give the title compound.

Workup

  1. customThe solvent is removed to dryness
  2. additionH2O is added
  3. filtrationThe solid is filtered
  4. customdried

Sources & evidence

ORD record
ord-addbbf4343454f61b3a7044fb462cd9f
Source dataset
uspto-grants-2015_09
Patent number
US09133204B2

Reaction notes

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