Hydrochloric Acid → HCID 67278834, compound

HRID 2279665Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][C:11]([CH2:44][O:45][C:46]2[CH:51]=[CH:50][C:49]([N:52]3[CH2:56][C@H:55]([CH2:57][NH:58][C:59](=[O:61])[CH3:60])[O:54][C:53]3=[O:62])=[CH:48][C:47]=2[F:63])([O:14][C:15](=[O:43])[CH:16]([NH:32][C:33]([O:35][CH2:36][C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)=[O:34])[CH2:17][CH2:18][CH2:19][CH2:20][NH:21][C:22]([O:24][CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[O:23])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:64]>CO>[ClH:64].[C:59]([NH:58][CH2:57][C@@H:55]1[O:54][C:53](=[O:62])[N:52]([C:49]2[CH:50]=[CH:51][C:46]([O:45][CH2:44][C:11]3([O:14][C:15](=[O:43])[CH:16]([NH:32][C:33]([O:35][CH2:36][C:37]4[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=4)=[O:34])[CH2:17][CH2:18][CH2:19][CH2:20][NH:21][C:22]([O:24][CH2:25][C:26]4[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=4)=[O:23])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)=[C:47]([F:63])[CH:48]=2)[CH2:56]1)(=[O:61])[CH3:60]

Participants

Conditions

Temperature: 40 °C

Procedure

200 mg of 4-{4-[5-(5S)-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenoxymethyl}-4-(2,6-bis-benzyloxycarbonylamino-hexanoyloxy)-piperidine-1-carboxylic acid tert-butyl ester (MW: 977.97, 0.22 mmol) were dissolved in 4 ml of a 1.25M dry hydrochloric acid in methanol. The reaction was stirred at 40° C. for two hours, and the solvent removed by distillation under reduced pressure to leave a off white solid. Yield: 178 mg, quantitative. MS: 778.8 (M+H)+, Method ESI+.

Workup

customthe solvent removed by distillation under reduced pressure
customto leave a off white solid

Sources & evidence

ORD record: ord-c908e000b5804236a170e33de12d36ab
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09133213B2

Reaction notes

Loading…