反应详情

In a similar manner to Example 51, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (30.0 mg) and allylamine (14.0 μL) were used to obtain (2S,4S)-4-fluoro-1-[[N-[4-[N-(2-propenyl)amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile (15.7 mg).