反应详情

Prepared analogously to Compound 1B replacing Compound 1E with ethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)propylphosphinate (Compound 37C, 0.680 g, 1.50 mmol) and Compound 1C with Compound 6F (0.420 g, 1.52 mmol) to isolate the title compound as 650 mg of a light yellow solid (63%). MS (ESI): m/z 691.25 [M+H]+. UPLC: tR=0.98 min (polar—2 min).