Ethyl 3-aminopyridine-2-carboxylate → HCID 178476808, compound

Participants

Role	Name	HCID	Charge
Reactant	Ethyl 3-aminopyridine-2-carboxylate	HCID 565054	—
Reactant	Diethyl (4-{[4-({7-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate	HCID 58292892	—
Reactant	7-amino-4-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]-2-methyl-2,3-dihydro-1H-isoindol-1-one	HCID 67255122	—
Reactant	HCID 178476805	HCID 178476805	—
Product	HCID 178476808	HCID 178476808	—

Reaction Steps

Prepared analogously to Compound 1B replacing Compound 1E with ethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)propylphosphinate (Compound 37C, 0.680 g, 1.50 mmol) and Compound 1C with Compound 6F (0.420 g, 1.52 mmol) to isolate the title compound as 650 mg of a light yellow solid (63%). MS (ESI): m/z 691.25 [M+H]+. UPLC: tR=0.98 min (polar—2 min).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09133224B2
Source dataset	uspto-grants-2015_09
ORD ID	ord-3ca5b5b69d8f46408662803d2a455388
Source note	uspto-grants-2015_09