HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-({3-[(Benzyloxy)methyl]oxetan-3-yl}methyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole → (3-((4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)oxetan-3-yl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-({3-[(Benzyloxy)methyl]oxetan-3-yl}methyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole | HCID 67813116 | — |
| Reactant | Methyl 4-[5-({2-[(4-{[ethoxy(hydroxy)phosphoryl]methyl}-2-methoxyphenyl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)-6-(methylcarbamoyl)pyridin-2-yl]-1-(3-hydroxypropyl)-1H-pyrrole-2-carboxylate | HCID 86697760 | — |
| Product | (3-((4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)oxetan-3-yl)methanol | HCID 67813981 | 95.3% |
Reaction Steps
1-({3-[(Benzyloxy)methyl]oxetan-3-yl}methyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (Compound 44C, 1.37 mg, 3.56 mmol) was hydrogenated using the procedure from Compound 38A to afford 998 mg of the title compound (95%). 1H NMR (400 MHz, CD3OD) δ 7.86 (s, 1H), 7.67 (s, 1H), 4.65 (d, J=6.3 Hz, 2H), 4.49 (s, 2H), 4.42 (d, J=6.3 Hz, 2H), 3.57 (s, 2H), 1.32 (s, 12H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133224B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-f3310b915e704d40970b60439819b117 |
| Source note | uspto-grants-2015_09 |