反应详情

A mixture of 1,3-diol, 2-hydrazino (7B) (59 mg, 0.14 mmol) and p-toluene sulfonic acid monohydrate (2.7 mg, 0.014 mmol) in 5.0 mL anhydrous acetone was stirred at rt for 42 h. The reaction mixture was quenched with 5% NaHCO3 and extracted with CH2Cl2. The combined organic layers were dried over anhydrous Na2SO4, and removed in vacuo. Purification by flash chromatography on silica gel afforded the desired product as a white solid (94%).

1. customThe reaction mixture was quenched with 5% NaHCO3
2. extractionextracted with CH2Cl2
3. dry with materialThe combined organic layers were dried over anhydrous Na2SO4
4. customremoved in vacuo
5. customPurification by flash chromatography on silica gel