HRID228000

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID581091

2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid ethyl ester

C8H11N3O3S

结构：N#C[C@@H]1C[C@H](F)CN1C(=O)CNC12CCC(C(=O)O)(CC1)CC2

HCID57634365

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)C(=NOC)c1csc(NC(=O)C23CCC(NCC(=O)N4C[C@@H](F)C[C@H]4C#N)(CC2)CC3)n1

HCID86616456

未命名化合物

收率 52.5%

PROCEDURE

实验过程

In a similar manner to Example 87, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (50.0 mg) and ethyl 2-amino-α-methoxyiminothiazole-4-acetate (78.0 mg) were used to obtain (2S,4S)-1-[[N-[4-[N-[(1-ethoxycarbonyl-1-methoxyiminomethyl)thiazol-2-yl]amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (43.4 mg).