Ethyl 2-(2-aminothiazol-4-yl)-2-methoxyiminoacetate → HCID 86616456, compound

Participants

Role	Name	HCID	Charge
Reactant	Ethyl 2-(2-aminothiazol-4-yl)-2-methoxyiminoacetate	HCID 581091	—
Reactant	(2S,4S)-1-[[N-(4-carboxybicyclo[2,2,2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile	HCID 57634365	—
Product	HCID 86616456	HCID 86616456	52.5%

Reaction Steps

In a similar manner to Example 87, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (50.0 mg) and ethyl 2-amino-α-methoxyiminothiazole-4-acetate (78.0 mg) were used to obtain (2S,4S)-1-[[N-[4-[N-[(1-ethoxycarbonyl-1-methoxyiminomethyl)thiazol-2-yl]amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (43.4 mg).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07560569B2
Source dataset	uspto-grants-2009_07
ORD ID	ord-6998afd7bd18408eab8bc9c24d9e92e0
Source note	uspto-grants-2009_07