Cyclopentanone → Ethyl 3-(cyclopentylamino)-2,2-dimethylpropanoate

HRID 2280000Notes

Reaction equation

HRID 2280000 reaction equation
[CH2:1]([O:3][C:4](=[O:10])[C:5]([CH3:9])([CH3:8])[CH2:6][NH2:7])[CH3:2].[C:11]1(=O)[CH2:15][CH2:14][CH2:13][CH2:12]1.C([O-])(=O)C.[Na+].C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>C(Cl)Cl>[CH2:1]([O:3][C:4](=[O:10])[C:5]([CH3:9])([CH3:8])[CH2:6][NH:7][CH:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1)[CH3:2]

Participants

6

Reactant 4

HCID 8452CyclopentanoneHCID 421529Ethyl 3-amino-2,2-dimethylpropanoateHCID 517045Sodium AcetateHCID 5049666Sodium triacetoxyborohydride

Product 1

HCID 57969950Ethyl 3-(cyclopentylamino)-2,2-dimethylpropanoate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Reaction of 3-amino-2,2-dimethyl-propionic acid ethyl ester with cyclopentanone, sodium acetate and sodium triacetoxyborohydride in DCM gave 3-Cyclopentylamino-2,2-dimethyl-propionic acid ethyl ester

Sources & evidence

ORD record
ord-2b2b721d5b8a488b9e99df8e784d6cb1
Source dataset
uspto-grants-2015_09
Patent number
US09133199B2

Reaction notes

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