Benzenamine, 4-(phenylmethyl)- → (2s,4s)-4-Fluoro-1-[[n-[4-[n-(4-phenylmethylphenyl)amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile

Participants

Role	Name	HCID	Charge
Reactant	Benzenamine, 4-(phenylmethyl)-	HCID 136914	—
Reactant	(2S,4S)-1-[[N-(4-carboxybicyclo[2,2,2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile	HCID 57634365	—
Product	(2s,4s)-4-Fluoro-1-[[n-[4-[n-(4-phenylmethylphenyl)amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile	HCID 57756732	41.2%

Reaction Steps

In a similar manner to Example 63, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (50.0 mg) and 4-aminodiphenylmethane (62.0 mg) were used to obtain (2S,4S)-4-fluoro-1-[[N-[4-[N-(4-phenylmethylphenyl)amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile (31.1 mg).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07560569B2
Source dataset	uspto-grants-2009_07
ORD ID	ord-220319b9474e4ba4aabb7ed93d6b27bd
Source note	uspto-grants-2009_07