Hydrochloric Acid → (S)-2-nitro-6-(piperidin-3-ylmethoxy)benzonitrile hydrochloride
Reaction equation
[C:1]([C:3]1[C:23]([N+:24]([O-:26])=[O:25])=[CH:22][CH:21]=[CH:20][C:4]=1[O:5][CH2:6][C@H:7]1[CH2:12][CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8]1)#[N:2].[ClH:27]>O1CCOCC1>[ClH:27].[N+:24]([C:23]1[CH:22]=[CH:21][CH:20]=[C:4]([O:5][CH2:6][C@H:7]2[CH2:12][CH2:11][CH2:10][NH:9][CH2:8]2)[C:3]=1[C:1]#[N:2])([O-:26])=[O:25]Participants
Procedure
To a solution of (S)-tert-butyl 3-((2-cyano-3-nitrophenoxy)methyl)piperidine-1-carboxylate (Example 1e, 41.74 g) in dioxane (115 mL) cooled to 0° C. in an ice bath was added a solution of 4N HCl in dioxane (70 mL, 280 mmol). The reaction mixture was stirred at room temperature overnight then evaporated under reduced pressure. Et2O (700 mL) was added to the residue and the suspension was refluxed for one hour. The solid was collected by filtration and dried under high vacuum to afford (S)-2-nitro-6-(piperidin-3-ylmethoxy)benzonitrile hydrochloride as a pale peach solid (24.64 g, 89% yield over two steps). 1H NMR (400 MHz, DMSO-d6) δ 1.47-1.30 (m, 1H). 1.77-1.62 (m, 1H), 1.84 (t, J=12.4 Hz, 2H), 2.32 (d, J=9.4 Hz, 1H), 2.87-2.68 (m, 2H), 3.27-3.16 (m, 2H), 4.15 (dd, J=9.7, 7.2 Hz, 1H), 4.25 (dd, J=9.7, 5.4 Hz, 1H), 7.72 (dd, J=7.6, 1.9 Hz, 1H), 7.96-7.86 (m, 2H), 9.20-8.89 (m, 2H). MS 262 (MH+).
Workup
- customthen evaporated under reduced pressure
- additionEt2O (700 mL) was added to the residue
- temperaturethe suspension was refluxed for one hour
- filtrationThe solid was collected by filtration
- customdried under high vacuum
Sources & evidence
- ORD record
- ord-bad931405a9d4e13bb0137ef1a87bab9
- Source dataset
- uspto-grants-2015_09
- Patent number
- US09138013B2
Reaction notes
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