反应详情

10-Bromodecanoic acid (2.51 g, 10 mmol) in acetone (50 mL) is treated with sodium azide (0.75 g, 11 mmol) at reflux for 2 h. The reaction is then concentrated in vacuo to a gum that is partitioned between ethyl acetate (50 mL) and water (50 mL). The organic phase is separated, dried over sodium sulfate and concentrated in vacuo to give 10-azidodecanoic acid (2.02 g, 95%).

1. temperatureat reflux for 2 h
2. concentrationThe reaction is then concentrated in vacuo to a gum that
3. customis partitioned between ethyl acetate (50 mL) and water (50 mL)
4. customThe organic phase is separated
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated in vacuo