Sodium Azide → 10-Azidodecanoic acid

Participants

Reaction Steps

10-Bromodecanoic acid (2.51 g, 10 mmol) in acetone (50 mL) is treated with sodium azide (0.75 g, 11 mmol) at reflux for 2 h. The reaction is then concentrated in vacuo to a gum that is partitioned between ethyl acetate (50 mL) and water (50 mL). The organic phase is separated, dried over sodium sulfate and concentrated in vacuo to give 10-azidodecanoic acid (2.02 g, 95%).

Provenance & Evidence