Hydrazine → HCID 178488695, compound

HRID 2280412Notes

Reaction equation

HRID 2280412 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:10](=O)[CH2:11][C:12]#[N:13])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[NH2:15][NH2:16]>C(O)C>[F:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:11]=[C:12]([NH2:13])[NH:16][N:15]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 247268133-(3-Fluoro-4-methoxyphenyl)-3-oxopropanenitrile

Product 1

HCID 178488695HCID 178488695, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3-(3-Fluoro-4-methoxyphenyl)-3-oxopropanenitrile (2.13 g, 11 mmol) and hydrazine (0.38 mL, 12.13 mmol) were combined in absolute ethanol and the reaction mixture was heated to reflux overnight. Then, the solvent and excess hydrazine were evaporated to provide the title compound in quantitative yield.

Workup

  1. temperaturethe reaction mixture was heated
  2. temperatureto reflux overnight
  3. customThen, the solvent and excess hydrazine were evaporated

Sources & evidence

ORD record
ord-c71eed9bdec84c09b2f888bcfd93972a
Source dataset
uspto-grants-2015_09
Patent number
US09139532B2

Reaction notes

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