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HRID228043

反应详情

EQUATION

反应方程式

HRID 228043 的结构方程式

REACTANTS

反应物

2
结构：Nc1ccc(N2CCCC2)cc1
HCID808841

4-(pyrrolidin-1-yl)aniline

C10H14N2

结构：N#C[C@@H]1C[C@H](F)CN1C(=O)CNC12CCC(C(=O)O)(CC1)CC2
HCID57634365

未命名化合物

PRODUCTS

生成物

1
结构：N#C[C@@H]1C[C@H](F)CN1C(=O)CNC12CCC(C(=O)Nc3ccc(N4CCCC4)cc3)(CC1)CC2
HCID57756856

未命名化合物

收率 18.9%

PROCEDURE

实验过程

In a similar manner to Example 63, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (50.0 mg) and 4-(pyrrolidin-1-yl)aniline (50.2 mg) were used to obtain (2S,4S)-1-[[N-[4-[N-[4-(pyrrolidin-1-yl)phenyl]amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (13.7 mg).