HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Pyrrolidin-1-yl)aniline → (2S,4S)-1-[[N-[4-[N-[4-(pyrrolidin-1-yl)phenyl]amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Pyrrolidin-1-yl)aniline | HCID 808841 | — |
| Reactant | (2S,4S)-1-[[N-(4-carboxybicyclo[2,2,2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile | HCID 57634365 | — |
| Product | (2S,4S)-1-[[N-[4-[N-[4-(pyrrolidin-1-yl)phenyl]amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile | HCID 57756856 | 18.9% |
Reaction Steps
In a similar manner to Example 63, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (50.0 mg) and 4-(pyrrolidin-1-yl)aniline (50.2 mg) were used to obtain (2S,4S)-1-[[N-[4-[N-[4-(pyrrolidin-1-yl)phenyl]amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (13.7 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07560569B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-41bd4979303d4b1abe5d79c1e0109aba |
| Source note | uspto-grants-2009_07 |