Benzenamine, 4-chloro-2-(trifluoromethyl)- → HCID 23150549, compound

HRID 228045Notes

Reaction equation

HRID 228045 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9]12[CH2:16][CH2:15][C:12]([C:17]([OH:19])=O)([CH2:13][CH2:14]1)[CH2:11][CH2:10]2)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:20][C:21]1[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:22]=1[C:28]([F:31])([F:30])[F:29]>>[C:1]([O:5][C:6]([NH:8][C:9]12[CH2:10][CH2:11][C:12]([C:17]([NH:20][C:21]3[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:22]=3[C:28]([F:31])([F:29])[F:30])=[O:19])([CH2:15][CH2:16]1)[CH2:13][CH2:14]2)=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 67961Benzenamine, 4-chloro-2-(trifluoromethyl)-HCID 231507384-{[(Tert-butoxy)carbonyl]amino}bicyclo[2.2.2]octane-1-carboxylic acid

Product 1

HCID 23150549HCID 23150549, compound

Procedure

In a similar manner to Example 133, 4-tert-butoxycarbonylaminobicyclo[2.2.2]octane-1-carboxylic acid (150 mg) and 2-amino-5-chlorobenzotrifluoride (173 μL) were used to obtain 4-tert-butoxycarbonylamino-N-(4-chloro-2-trifluoromethylphenyl)bicyclo[2.2.2]octane-1-carboxamide (79.7 mg).

Sources & evidence

ORD record
ord-783b1943a1ab4a6891dd2fd1f5e19d51
Source dataset
uspto-grants-2009_07
Patent number
US07560569B2

Reaction notes

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