2-Fluoro-4-(trifluoromethyl)aniline → HCID 23150664, compound

HRID 228048Notes

Reaction equation

HRID 228048 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9]12[CH2:16][CH2:15][C:12]([C:17](O)=[O:18])([CH2:13][CH2:14]1)[CH2:11][CH2:10]2)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][C:22]=1[F:31]>>[C:1]([O:5][C:6]([NH:8][C:9]12[CH2:10][CH2:11][C:12]([C:17]([NH:20][C:21]3[CH:26]=[CH:25][C:24]([C:27]([F:28])([F:29])[F:30])=[CH:23][C:22]=3[F:31])=[O:18])([CH2:15][CH2:16]1)[CH2:13][CH2:14]2)=[O:7])([CH3:2])([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 27376742-Fluoro-4-(trifluoromethyl)anilineHCID 231507384-{[(Tert-butoxy)carbonyl]amino}bicyclo[2.2.2]octane-1-carboxylic acid

Product 1

HCID 23150664HCID 23150664, compound

Procedure

In a similar manner to Example 133, 4-tert-butoxycarbonylaminobicyclo[2.2.2]octane-1-carboxylic acid (100 mg) and 4-amino-3-fluorobenzotrifluoride (106 μL) were used to obtain 4-tert-butoxycarbonylamino-N-(2-fluoro-4-trifluoromethylphenyl)bicyclo[2.2.2]octane-1-carboxamide (58.6 mg).

Sources & evidence

ORD record
ord-3e0ed2d8e2ac4dbba4906dbc572c3207
Source dataset
uspto-grants-2009_07
Patent number
US07560569B2

Reaction notes

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