Methyl 2-[4-benzylpiperazinyl]benzoate → Methyl 2-(piperazin-1-yl)benzoate

HRID 228074Notes

Reaction equation

HRID 228074 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:23]=[CH:22][CH:21]=[CH:20][C:15]=2[C:16]([O:18][CH3:19])=[O:17])[CH2:10][CH2:9]1)C1C=CC=CC=1>[Pd]>[N:11]1([C:14]2[CH:23]=[CH:22][CH:21]=[CH:20][C:15]=2[C:16]([O:18][CH3:19])=[O:17])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

3

Reactant 1

HCID 21935101Methyl 2-[4-benzylpiperazinyl]benzoate

Product 1

HCID 10932975Methyl 2-(piperazin-1-yl)benzoate

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The title compound was prepared according to the procedure described in Preparation IV by using methyl 2-[4-benzylpiperazinyl]benzoate (2.8 g, 8.9 mmol), 10% Pd/C (Aldrich) (940 mg), and HCO2NH4 (2.8, 44 mmol). The title compound was isolated as a colorless oil (1.75 g). (MS (ESI, pos. ion) m/z: 221 (M+H). Calc'd for C12H16N2O2: 220.12.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-01e8de75eefe4ceb950ef10f879436f3
Source dataset
uspto-grants-2009_07
Patent number
US07560460B2

Reaction notes

Loading…