反应详情

温度

10 °C

A 3-L, 3-neck, round bottom flask was equipped with a mechanical stirrer, a J-KEM temperature controller, a nitrogen inlet, and a 125 mL addition funnel. The flask was flushed with nitrogen and charged with 4-hydroxybicyclo[2.2.1]heptane-1-carboxylic acid (53 g, 339 mmol) and anhydrous toluene (350 mL). The reaction mixture was cooled to 10° C. and treated with benzyl alcohol (175 mL, 1.695 mol). The reaction mixture was then slowly treated with DIEA (118 mL, 678 mmol) and diphenylphosphonic azide (87.7 mL, 407 mmol). The reaction mixture was slowly heated up to 50° C. when off-gassing began. The heating mantle was removed and the reaction mixture slowly exothermed up to 75° C. while off-gassing considerably. The reaction was heated to 110° C. and stirred for 20 h when TLC analysis (10% methanol/ethyl acetate) indicated a complete reaction. The reaction mixture was concentrated to remove solvent and partitioned between ethyl acetate (1.2 L) and brine (700 mL). The organic layer was dried over sodium sulfate, concentrated, and purified by silica gel chromatography (20-60% ethyl acetate/hexane) providing 61 g (69%) of benzyl 4-hydroxybicyclo[2.2.1]heptan-1-ylcarbamate; MS (ESI) m/z 260.1 [M+1]−

1. additiona J-KEM temperature controller, a nitrogen inlet, and a 125 mL addition funnel
2. customThe flask was flushed with nitrogen
3. temperatureThe reaction mixture was slowly heated up to 50° C. when
4. customThe heating mantle was removed
5. customslowly exothermed up to 75° C.
6. temperatureThe reaction was heated to 110° C.
7. customa complete reaction
8. concentrationThe reaction mixture was concentrated
9. customto remove solvent
10. custompartitioned between ethyl acetate (1.2 L) and brine (700 mL)
11. dry with materialThe organic layer was dried over sodium sulfate
12. concentrationconcentrated
13. custompurified by silica gel chromatography (20-60% ethyl acetate/hexane)