Sodium hydride → DLinDMA

HRID 2280988Notes

Reaction equation

HRID 2280988 reaction equation
[H-].[Na+].[CH3:3][N:4]([CH3:10])[CH2:5][CH:6]([OH:9])[CH2:7][OH:8].CS(O[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]/[CH:24]=[CH:25]\[CH2:26]/[CH:27]=[CH:28]\[CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])(=O)=O>C1C=CC=CC=1>[CH2:16]([O:8][CH2:7][CH:6]([O:9][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]/[CH:24]=[CH:25]\[CH2:26]/[CH:27]=[CH:28]\[CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])[CH2:5][N:4]([CH3:10])[CH3:3])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]/[CH:24]=[CH:25]\[CH2:26]/[CH:27]=[CH:28]\[CH2:29][CH2:30][CH2:31][CH2:32][CH3:33]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 790783-(Dimethylamino)-1,2-propanediolHCID 59753235Linoleyl methanesulfonate

Product 1

HCID 11570822DLinDMAYield 123.6%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent3×

Procedure

To a suspension of NaH (95%, 5.2 g, 0.206 mol) in 120 mL of anhydrous benzene was added dropwise N,N-dimethyl-3-aminopropane-1,2-diol (2.8 g, 0.0235 mol) in 40 mL of anhydrous benzene under argon. Upon addition, the resulting mixture was stirred at room temperature for 15 min. Linoleyl methane sulfonate (99%, 20 g, 0.058 mol) in 75 mL of anhydrous benzene was added dropwise at room temperature under argon to the above mixture. After stirred at room temperature for 30 min., the mixture was refluxed overnight under argon. Upon cooling, the resulting suspension was treated dropwise with 250 mL of 1:1 (V:V) ethanol-benzene solution. The organic phase was washed with water (150 mL), brine (2×200 mL), and dried over anhydrous sodium sulfate. Solvent was evaporated in vacuo to afford 17.9 g of light oil as a crude product. 10.4 g of pure DLinDMA were obtained upon purification of the crude product by column chromatography twice on silica gel using 0-5% methanol gradient in methylene chloride. 1H NMR (400 MHz, CDCl3) δ: 5.35 (8H, m, CH═CH), 3.5 (7H, m, OCH), 2.75 (4H, t, 2×CH2), 2.42 (2H, m, NCH2), 2.28 (6H, s, 2×NCH3), 2.05 (8H, q, vinyl CH2), 1.56 (4H, m, 2×CH2), 1.28 (32H, m, 16×CH2), 0.88 (6H, t, 2×CH3) ppm.

Workup

  1. additionUpon addition
  2. stirringAfter stirred at room temperature for 30 min.
  3. temperaturethe mixture was refluxed overnight under argon
  4. temperatureUpon cooling
  5. washThe organic phase was washed with water (150 mL), brine (2×200 mL)
  6. dry with materialdried over anhydrous sodium sulfate
  7. customSolvent was evaporated in vacuo

Sources & evidence

ORD record
ord-b48e33c9c1be4d8e9d3616848f006ecb
Source dataset
uspto-grants-2015_09
Patent number
US09139554B2

Reaction notes

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