Cyanide → HCID 86717868, compound

Participants

Reaction Steps

The protected 3-hydroxy-4-methoxy-benzaldehyde, anhydrous ethanol, benzyl amine and acetic acid were sequentially added into a three-necked flask, dissolved with stirring, and reacted at reflux. Subsequently, potassium carbonate, isonitrile and tetrahydrofuran were successively added. The mixture was reacted at 50° C. with stirring. After cooling, the ethanol was evaporated under reduced pressure. The residue was purified by silica gel column chromatography to give a solid. Then, the solid was subjected to reduction over palladium on carbon and ammonium formate using methanol as a solvent to afford the desired product, as a white solid, melting point: 181.1˜182.4° C.

Provenance & Evidence