HCID 117772123, compound → HCID 117774665, compound

HRID 2281091Notes

Reaction equation

HRID 2281091 reaction equation
[N+:1]([C:4]1[C:5]([O:10][C@H:11]([CH3:20])[C:12]([NH:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[O:13])=[N:6][CH:7]=[CH:8][CH:9]=1)([O-])=O>CO>[NH2:1][C:4]1[C:5]([O:10][C@H:11]([CH3:20])[C:12]([NH:14][CH2:15][C:16]([F:19])([F:17])[F:18])=[O:13])=[N:6][CH:7]=[CH:8][CH:9]=1

Participants

3

Reactant 1

HCID 117772123HCID 117772123, compound

Product 1

HCID 117774665HCID 117774665, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 500 mg (1.7 mmol) (2R)-2-[(3-nitro-2-pyridyl)oxy]-N-(2,2,2-trifluoroethyl)propanamide 100 mg Raney-Nickel and MeOH are added and the mixture is hydrogenated in a Parr apparatus (RT; 3 bar; over night). The catalyst is filtered off and the solvent is evaporated.

Workup

  1. customis hydrogenated in a Parr apparatus (RT; 3 bar; over night)
  2. filtrationThe catalyst is filtered off
  3. customthe solvent is evaporated

Sources & evidence

ORD record
ord-56e006f3758f41eaa0f3088cb5be23e0
Source dataset
uspto-grants-2015_09
Patent number
US09139577B2

Reaction notes

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