HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2281102Generated: November 1, 2026
Methanol → 2-[[7-[[Dimethyl(oxo)-lambda6-sulfanylidene]amino]-5-methyl-quinazolin-4-yl]amino]-5-fluoro-phenol
https://huagongshe.com/reaction/2281102
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | N-(2-benzyloxy-4-fluoro-phenyl)-7-[[dimethyl(oxo)-lambda6-sulfanylidene]amino]-5-methyl-quinazolin-4-amine | HCID 86718469 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-[[7-[[Dimethyl(oxo)-lambda6-sulfanylidene]amino]-5-methyl-quinazolin-4-yl]amino]-5-fluoro-phenol | HCID 86718471 | — |
Reaction Steps
To 0.5 g (1.1 mmol) of N-(2-benzyloxy-4-fluoro-phenyl)-7-[[dimethyl(oxo)-λ6-sulfanylidene]amino]-5-methyl-quinazolin-4-amine are added 50 mg palladium on charcoal (10%) and MeOH and THF and mixture is hydrogenated in a Parr apparatus (RT; 3 bar; 3 h). DMF and Ethanol are added and mixture heated to 70° C., the catalyst is filtered off and the solvent is evaporated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09139577B2 |
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| Source dataset | uspto-grants-2015_09 |
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| ORD ID | ord-c6695fb144b5457d8ed1cb5546f4384c |
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| Source note | uspto-grants-2015_09 |
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