Acetyl chloride → HCID 22591916, compound

HRID 22812Notes

Reaction equation

HRID 22812 reaction equation
[NH2:1][C:2]1[C:7]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[CH:16]1([N+:22]#[C-:23])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1.Cl(O)(=O)(=O)=O.[C:29](Cl)(=[O:31])[CH3:30]>C(Cl)Cl>[CH2:9]([O:8][C:7]1[C:2]2[N:3]([C:23]([N:22]([CH:16]3[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]3)[C:29](=[O:31])[CH3:30])=[C:9]([CH:10]3[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]3)[N:1]=2)[CH:4]=[CH:5][CH:6]=1)[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

6

Reactant 4

HCID 6367Acetyl chlorideHCID 24247Perchloric AcidHCID 79129Cyclohexyl isocyanideHCID 903342-Amino-3-benzyloxypyridine

Product 1

HCID 22591916HCID 22591916, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Compound (35) was prepared from 1.0 ml of 2-amino-3-benzyloxypyridine solution (0.1 M, DCM), 0.575 ml of cyclohexyl isocyanide solution (0.2 M, DCM), 0.500 ml of cyclohexylcarbaldehyde solution (0.3 M, DCM), and 10 μl of perchloric acid (w=20%), and reaction with acetyl chloride. Excess acetyl chloride was removed under reduced pressure.

Workup

  1. customExcess acetyl chloride was removed under reduced pressure

Sources & evidence

ORD record
ord-63d553290ff446fab31f0207fdebba7d
Source dataset
uspto-grants-2005_02
Patent number
US06849642B2

Reaction notes

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