反应详情

A suspension of tert-butyl 9-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-6,9-diazaspiro[4.5]decane-6-carboxylate (80 mg, 0.20 mmol) in dioxane (200 L) was treated with a solution of hydrochloric acid in dioxane (4.0 M, 200 L). After shaking for 3 hours, the solution was treated with additional hydrochloric acid in dioxane (4.0 M, 100 L). After shaking an additional sixteen hours, the solvents were removed in vacuo to provide 9-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-9-aza-6-azoniaspiro[4.5]decane chloride which was carried on without further purification.

1. stirringAfter shaking an additional sixteen hours
2. customthe solvents were removed in vacuo