HCID 66643955, compound → HCID 66643986, compound

HRID 2281324Notes

Reaction equation

HRID 2281324 reaction equation
[Br:1][C:2]1[CH:11]=[CH:10][C:5]2[C:6](=[O:9])[O:7][CH2:8][C:4]=2[C:3]=1[CH:12]=[CH2:13]>CO.[Pd]>[Br:1][C:2]1[CH:11]=[CH:10][C:5]2[C:6](=[O:9])[O:7][CH2:8][C:4]=2[C:3]=1[CH2:12][CH3:13]

Participants

4

Reactant 1

HCID 66643955HCID 66643955, compound

Product 1

HCID 66643986HCID 66643986, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 5-bromo-4-vinyl-2-benzofuran-1(3H)-one (2.0 g, 8.37 mmol) and Pd/C (400 mg) in 50 mL of MeOH was stirred at room temperature under H2 (1 atm) overnight, and then filtered. The filtrate was concentrated. The resulting oil was purified by column chromatography to give 5-bromo-4-ethyl-2-benzofuran-1(3H)-one.

Workup

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated
  3. customThe resulting oil was purified by column chromatography

Sources & evidence

ORD record
ord-9ed906ebc12a46938cd929febfebae01
Source dataset
uspto-grants-2015_09
Patent number
US09139585B2

Reaction notes

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