4-(1H-1,2,3,4-tetrazol-1-yl)benzene-1-sulfonyl chloride → 5-((R)-1-Hydroxy-2-((1S,4S)-5-(4-(1H-tetrazol-1-yl)phenylsulfonyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)ethyl)-4-methylisobenzofuran-1 (3H)-one

Participants

Reaction Steps

5-((R)-1-Hydroxy-2-((1S,4S)-5-(4-(1H-tetrazol-1-yl)phenylsulfonyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)ethyl)-4-methylisobenzofuran-1 (3H)-one was prepared in a similar fashion to that described for the synthesis of EXAMPLE 14 starting from 5-((R)-2-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-1-hydroxyethyl)-4-methylisobenzofuran-1(3H)-one hydrochloride (INTERMEDIATE 15) and commercially available 4-(1H-tetrazol-1-yl)benzene-1-sulfonyl chloride.

Provenance & Evidence