HCID 86636612, compound → HCID 44467020, compound

HRID 2281400Notes

Reaction equation

HRID 2281400 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([NH:16][C:17]3[N:22]=[C:21]([N:23]4[CH2:28][CH2:27][CH2:26][CH2:25][CH:24]4[CH2:29][NH:30]C(=O)OC(C)(C)C)[C:20]([F:38])=[CH:19][N:18]=3)=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]>C(O)(C(F)(F)F)=O>[NH2:30][CH2:29][CH:24]1[CH2:25][CH2:26][CH2:27][CH2:28][N:23]1[C:21]1[C:20]([F:38])=[CH:19][N:18]=[C:17]([NH:16][C:13]2[CH:12]=[CH:11][C:10]([N:7]3[CH2:8][CH2:9][N:4]([C:1](=[O:3])[CH3:2])[CH2:5][CH2:6]3)=[CH:15][CH:14]=2)[N:22]=1

Participants

3

Reactant 1

HCID 86636612HCID 86636612, compound

Product 1

HCID 44467020HCID 44467020, compoundYield 74.4%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of tert-butyl (1-(2-(4-(4-acetylpiperazin-1-yl)phenylamino)-5-fluoropyrimidin-4-yl)piperidin-2-yl)methylcarbamate (56 mg, 0.11 mmol) in TFA (3 mL) was stirred at room temperature for 60 min. TFA was removed in vacuo. The residue was purified by HPLC to give the titled compound (35 mg) MS 428.4 (M+H); UV 213.8, 258.8 nm.

Workup

  1. customTFA was removed in vacuo
  2. customThe residue was purified by HPLC

Sources & evidence

ORD record
ord-4ff0b13d5f7b47aca07668f168b2c936
Source dataset
uspto-grants-2015_09
Patent number
US09139581B2

Reaction notes

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