Benzaldehyde → HCID 59729915, compound

HRID 228168Notes

Reaction equation

HRID 228168 reaction equation
[NH2:1][CH2:2][C:3]([C:6]1[CH:21]=[CH:20][C:9]([O:10][C:11]2[CH:19]=[CH:18][C:14]([C:15]([NH2:17])=[O:16])=[CH:13][N:12]=2)=[CH:8][CH:7]=1)([CH3:5])[CH3:4].[CH:22](=O)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[CH2:22]([NH:1][CH2:2][C:3]([C:6]1[CH:7]=[CH:8][C:9]([O:10][C:11]2[CH:19]=[CH:18][C:14]([C:15]([NH2:17])=[O:16])=[CH:13][N:12]=2)=[CH:20][CH:21]=1)([CH3:5])[CH3:4])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 240BenzaldehydeHCID 59730297HCID 59730297, compound

Product 1

HCID 59729915HCID 59729915, compound

Procedure

Using a method similar to example 35, using 6-[4-(2-amino-1,1-dimethyl-ethyl)-phenoxy]-nicotinamide (example 193), and benzaldehyde affords the title compound: HPLC (5/95 to 95/5 ACN/(0.1% TFA in water) Zorbax SB-Phenyl Column 4.6 mm×15 cm×5 micron: Retention time: 6.01 minutes, Purity: 95.6%; mass spectrum (ion spray): m/z=376.1 (M+1).

Sources & evidence

ORD record
ord-7c7d89401d2c40ea8f60a2053836f90a
Source dataset
uspto-grants-2009_07
Patent number
US07560463B2

Reaction notes

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