Oxycodone Hydrochloride → Oxycodone

HRID 2281980Notes

Reaction equation

HRID 2281980 reaction equation
[CH3:1][N:2]1[C@@H:19]2[CH2:20][C:7]3[CH:8]=[CH:9][C:10]([O:22][CH3:23])=[C:11]4[O:12][C@H:13]5[C:14]([CH2:16][CH2:17][C@:18]2([OH:21])[C@:5]5([C:6]=34)[CH2:4][CH2:3]1)=[O:15].Cl>C(Cl)(Cl)Cl>[CH3:1][N:2]1[C@@H:19]2[CH2:20][C:7]3[CH:8]=[CH:9][C:10]([O:22][CH3:23])=[C:11]4[O:12][C@H:13]5[C:14]([CH2:16][CH2:17][C@:18]2([OH:21])[C@:5]5([C:6]=34)[CH2:4][CH2:3]1)=[O:15]

Participants

3

Reactant 1

HCID 5462350Oxycodone Hydrochloride

Product 1

HCID 5284603OxycodoneYield 93%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Oxycodone hydrochloride (10.0 g, 28.5 mmol) was dissolved in chloroform (150 mL) and washed with 5% aq. NaHCO3 (50 mL). The organic layer was dried over MgSO4 and evaporated. The residue was dried under vacuum overnight to provide oxycodone free base (8.3 g, 93%) as a white solid.

Workup

  1. washwashed with 5% aq. NaHCO3 (50 mL)
  2. dry with materialThe organic layer was dried over MgSO4
  3. customevaporated
  4. customThe residue was dried under vacuum overnight

Sources & evidence

ORD record
ord-45d7bf76e1df4894bd5f1cd7b4e8496a
Source dataset
uspto-grants-2015_09
Patent number
US09139612B2

Reaction notes

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