1-Bromo-4-[(2,2-dimethoxyethyl)sulfanyl]benzene → 5-Bromo-1-benzothiophene
Reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:9][CH:10](OC)OC)=[CH:4][CH:3]=1>ClC1C=CC=CC=1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]2[S:8][CH:9]=[CH:10][C:4]=2[CH:3]=1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 180 °C
Procedure
A mixture of polyphosphoric acid (5.0 g) and chlorobenzene (100 mL) was refluxed for three hours, and then to the mixture was added 1-bromo-4-(2,2-dimethoxyethyl-sulfenyl)benzene (2.50 g, 9.00 mmol). The reaction mixture was stirred at 180° C. for two days.
Workup
- temperaturewas refluxed for three hours
Sources & evidence
- ORD record
- ord-aad2e6cfb133483e9286a68eb13091bc
- Source dataset
- uspto-grants-2015_09
- Patent number
- US09139774B2
Reaction notes
Loading…