HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2282082Generated: November 1, 2026
1-Bromo-4-[(2,2-dimethoxyethyl)sulfanyl]benzene → 5-Bromo-1-benzothiophene
https://huagongshe.com/reaction/2282082
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Bromo-4-[(2,2-dimethoxyethyl)sulfanyl]benzene | HCID 14175760 | — |
| Solvent | Chlorobenzene | HCID 7964 | — |
| Product | 5-Bromo-1-benzothiophene | HCID 2776578 | — |
Reaction Steps
A mixture of polyphosphoric acid (5.0 g) and chlorobenzene (100 mL) was refluxed for three hours, and then to the mixture was added 1-bromo-4-(2,2-dimethoxyethyl-sulfenyl)benzene (2.50 g, 9.00 mmol). The reaction mixture was stirred at 180° C. for two days.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09139774B2 |
|---|
| Source dataset | uspto-grants-2015_09 |
|---|
| ORD ID | ord-aad2e6cfb133483e9286a68eb13091bc |
|---|
| Source note | uspto-grants-2015_09 |
|---|
