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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2282181Generated: November 1, 2026

Hydrazine hydrate (1:1) → HCID 178433738, compound

https://huagongshe.com/reaction/2282181

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrazine hydrate (1:1)HCID 24654—
ReactantDimethylformamide dimethyl acetalHCID 78373—
ReactantHCID 66855548HCID 66855548—
SolventAcetic AcidHCID 176—
ProductHCID 178433738HCID 17843373868%

Reaction Steps

Using 4-cyclohexyl-2-(2-methylpyrazolo[1,5-a]pyridin-3-yl)-1,3-thiazole-5-carboxamide (200 mg, 0.6 mmol), N,N-dimethylformamide dimethyl acetal (15 mL), acetic acid (25 mL) and hydrazine monohydrate (0.3 mL) as starting materials and in the same manner as in Example 13-B (vi), the title compound (146 mg, 68%) was obtained as a white solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09139589B2
Source datasetuspto-grants-2015_09
ORD IDord-77c56d9df72a487d81c8a20091db1488
Source noteuspto-grants-2015_09