Hydrazine hydrate (1:1) → HCID 178433738, compound

HRID 2282181Notes

Reaction equation

HRID 2282181 reaction equation
[CH:1]1([C:7]2[N:8]=[C:9]([C:15]3[C:16]([CH3:24])=[N:17][N:18]4[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=34)[S:10][C:11]=2[C:12]([NH2:14])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.COC(OC)[N:28]([CH3:30])C.O.[NH2:34]N>C(O)(=O)C>[CH:1]1([C:7]2[N:8]=[C:9]([C:15]3[C:16]([CH3:24])=[N:17][N:18]4[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=34)[S:10][C:11]=2[C:12]2[NH:28][CH:30]=[N:34][N:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 78373Dimethylformamide dimethyl acetalHCID 66855548HCID 66855548, compound

Product 1

HCID 178433738HCID 178433738, compoundYield 68%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Using 4-cyclohexyl-2-(2-methylpyrazolo[1,5-a]pyridin-3-yl)-1,3-thiazole-5-carboxamide (200 mg, 0.6 mmol), N,N-dimethylformamide dimethyl acetal (15 mL), acetic acid (25 mL) and hydrazine monohydrate (0.3 mL) as starting materials and in the same manner as in Example 13-B (vi), the title compound (146 mg, 68%) was obtained as a white solid.

Sources & evidence

ORD record
ord-77c56d9df72a487d81c8a20091db1488
Source dataset
uspto-grants-2015_09
Patent number
US09139589B2

Reaction notes

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