Sulfuryl chloride → Ethyl 2-chloro-2-(2-fluorobenzoyl)acetate

HRID 2282184Notes

Reaction equation

HRID 2282184 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:15])[CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11].S(Cl)([Cl:19])(=O)=O>C(OCC)C>[Cl:19][CH:9]([C:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[F:1])=[O:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11]

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 296342Ethyl 3-(2-fluorophenyl)-3-oxopropanoate

Product 1

HCID 18473854Ethyl 2-chloro-2-(2-fluorobenzoyl)acetateYield 97.2%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Using ethyl 3-(2-fluorophenyl)-3-oxopropanoate (1.0 g, 4.75 mmol), sulfuryl chloride (771 mg, 5.7 mmol) and diethyl ether (50 mL) as starting materials and in the same manner as in Example 20-B (i), the title compound (1.13 g, 97%) was obtained as a colorless oil.

Sources & evidence

ORD record
ord-9ce64de50760429caf0177a60c20e3e3
Source dataset
uspto-grants-2015_09
Patent number
US09139589B2

Reaction notes

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